There were no differences between the TL quartile groups in each cognitive stage group with regard to age, sex, education, body mass index (BMI), homocysteine level, total sleep time, Mini Nutritional Assessment (MNA) and Geriatric Depression Scale (GDS) scores, or the prevalence of hypertension, DM, dyslipidemia, current smoking, current drinking, sarcopenia, APOE ε4 carriers, or for participants that met the World Health Organization PA guidelines (≥ 600 metabolic equivalent minutes of PA per week) [23] (Supplementary Table 1). The gene discussed is APOE; the disease is major depressive disorder.