Another group showed that three weeks of repeated intraperitoneal BHB administration ameliorated depressive behaviors in a mouse model of depression involving spatial restraint stress and dexamethasone administration, as BHB administration increased histone3‐lysine9‐β‐hydroxybutyrylation, leading to upregulated expression of brain‐derived neurotrophic factor (BDNF) 14. Here, BDNF is linked to depressive disorder.