RIOK2 and central nervous system cancer: Next, we demonstrated that up‐regulation of miR‐4744 by its mimics significantly decreased the expression of RIOK2 at both mRNA (U251: P < .001; U118: P < .001) and protein (U251: P = .003; U118: P < .001) levels in glioma cells (Figure 5A‐B), indicating that RIOK2 is probably a target gene of miR‐4744.