RIOK2 and central nervous system cancer: As for the glioma subgroups, the up‐regulation of RIOK2‐mRNA was mostly attributed to Grade III (P = .035) and Grade IV groups (P = .059), while the down‐regulation of miR‐4744 level was mainly based on Grade II (P = .116) and Grade III (P = .060) glioma tissues (Figure 9B, D).