Consistent with our results, the expression level of plasma miR‐320d was significantly reduced in patients with adenoma or colorectal cancer (CRC) patients compared to the healthy controls, suggesting circulating miR‐320d was promising for early diagnosis of CRC.20 Cancer stem cells (CSCs) are subpopulations of cancer cells driving tumor growth and heterogeneity.21 The miR‐320d level was remarkably lower in CD133‐positive colon CSCs than in the CD133‐negative controls,22 indicating miR‐320d might play a key role in maintaining stemness and tumorigenicity of CSCs. This evidence concerns the gene PROM1 and adenoma.