Cox regression revealed that a tumour number equal or greater to two (HR 1.54), AFP > 400 μg/l (HR 1.14), serum albumin < 3.6 g/dl (HR 1.63) and total bilirubin > 0.9 mg/dl (HR 1.58) were independent risk factors in our population, excluding patients with subsequent LTX. This evidence concerns the gene ALB and neoplasm.