INS and type 1 diabetes mellitus: More similarities than differences have also been observed in insulin-naive T2D patients comparing both the second-generation long-acting insulins in a randomized head-to-head clinical trial with respect to efficacy on HbA1c reduction and hypoglycemic events.16 So far, no head-to-head clinical trial has been conducted in patients with T1D in daily life conditions comparing the effect of Deg-100 versus Gla-300 on glycemic control and glucose variability using continuous glucose monitoring (CGM).