Finally, in another study patients with severe CHF (NYHA-III-IV) were recruited, the majority of whom had markedly low exercise capacity and oxygen uptake, although only two participants were diagnosed as malnourished (identified as having two nutritional-related variables as subnormal, one of which was anthropometric (weight index, triceps skinfold thickness and arm muscle circumference) and one of which was biochemical (transthyretin and albumin)). This evidence concerns the gene TTR and congestive heart failure.