There were significant differences between the groups in cT (cT1, cT2 versus cT3) (P = 0.0103), the mean pathological tumor size (P = 0.0017), the mean pathological invasive tumor size (P < 0.0001), pT (P < 0.0001), ER (P = 0.0070), PgR (P = 0.0031), and Ly (P < 0.0001). This evidence concerns the gene ESR1 and neoplasm.