MAP1LC3A and obesity due to melanocortin 4 receptor deficiency: Next, SIRT1-mediated deacetylation of nuclear LC3 at Lys49 and Lys51 residues initiates LC3 translocation to the cytoplasm via a diabetes and obesity regulated (DOR/TP53INP2)-dependent interaction with deacetylated LC3 (Huang et al. 2015).