Our previous studies3 revealed that an important step in the TNFR2 signaling pathway in ccRCC linked to cell‐cycle entry involves cross‐talk between phosphorylation of VEGFR2 at tyrosine‐1059 (pVEGFR2Y1059) and cytosolic protein tyrosine kinase Etk. The gene discussed is TNFRSF1B; the disease is nonpapillary renal cell carcinoma.