To confirm the involvement of the VEGFR2/PI‐3K/Akt/mTORC pathway in TNFR2‐mediated pSTAT3Ser727 in ccRCC‐CD133+CSCs, we assessed the effect of specific inhibitors to these kinases either alone or in combination with wtTNF, R1TNF or R2TNF. This evidence concerns the gene KDR and nonpapillary renal cell carcinoma.