However, in contrast to ccRCC‐CD133+CSCs, activation of the kinase cascade appears to predominantly involve Akt and mTOR, with less activation of VEGFR2 and PI3K (Figure S5A‐D) and specific inhibition of Akt and mTOR resulted in a diminished R2TNF‐mediated pSTAT3Ser727 induction (Figure S6A,B) and cell death but significantly less (~2‐fold) compared to that observed in ccRCC‐CD133+CSCs (Table S1). Here, TNFRSF1B is linked to nonpapillary renal cell carcinoma.