In comparison to UT controls, which showed a rare signal, R2TNF induced a marked signal for TNFR2 or pSTAT3Ser727 expression in mitochondria in ccRCC‐CD133+CSCs (Figure 4C), also detected by IGEM (Figure 4D). This evidence concerns the gene TNFRSF1B and nonpapillary renal cell carcinoma.