Knockdown of TNFR1 signals also induced a small degree of cell death in NK‐CD133+cells and as in ccRCC‐CD133+CSCs, absence of all three signals induced an even higher level of cell death but significantly less(~2‐fold) than in ccRCC‐CD133+CSCs (Figure S7C). The gene discussed is TNFRSF1A; the disease is nonpapillary renal cell carcinoma.