As they persist after cytotoxic treatment, they can give rise through cell division and differentiation to tumor cell progeny and tumor recurrence.7 Based on these CSCs properties, it has been proposed that their elimination can halt neoplastic expansion.8 CD133, alone or in combination with other molecular markers, has been used to isolate stem cells from normal kidney and CSCs from RCC. This evidence concerns the gene PROM1 and neoplasm.