PTGS2 and early-onset autosomal dominant Alzheimer disease: First, COX2 has been suggested to be involved in the development and/or progression of age‐related human diseases including atherosclerosis, arthritis, cancer, diabetes, osteoporosis, and Alzheimer's disease.50, 51, 52, 53, 54, 55 Second, COX2 expression is increased in the tissues of aged humans and mice.