PTGS2 and cancer: Similar to cancer cells, senescent cells make use of various pro‐survival mechanisms to remain viable and rely on antiapoptotic pathways to persist in tissues.72 Such mechanisms include, but not limited to, Bcl‐2/Bcl‐xL, PI3K, and p21.72, 73, 74, 75 We have found that incubation with aspirin or celecoxib, a COX2‐specific inhibitor, decreases the viability of senescent fibroblasts and reduces the level of Bcl‐xL.