KRAS and myelodysplastic syndrome: Ras isoforms are ubiquitously expressed and highly homologous, but have specific and distinct molecular functions.1 In acute myeloid leukemia (AML) and related myelodysplastic syndromes, the most frequently mutated genes are N‐ and Kras. 3 Despite the high frequency of N‐ and Kras mutations in AML, the precise roles of ras oncogenes in leukemogenesis remain unclear.