GSK3A and neoplasm: Furthermore, the knockdown of both GSK3α and GSK3β resulted in aggressive AML.54 The GSK3 proteins have been implicated in many signaling pathways and act as both tumor suppressors and tumor enhancers.33 Thus, the GSK3s and β‐catenin are important elements in DMSO‐induced differentiation of HL‐60 cells.