This study therefore focused on novel functions of Kras and Kras‐mediated signaling networks in the differentiation of the human acute myeloid leukemia cell line HL‐60, which is one of the most common forms of leukemia cell lines and widely used in studies of human myeloid cell differentiation.15 HL‐60 cells are neutrophilic promyelocytes, which can be differentiated into neutrophil‐like, monocyte‐like, or eosinophil‐like cells depending on the method of differentiation. Here, KRAS is linked to leukemia.