LCN2 and diabetes mellitus: Urinary NGAL concentration has been found to be increased in diabetic subjects compared with healthy controls35 and to correlate negatively with eGFR, and positively with CysC, serum creatinine, and urea in patients with T2DM.36 Significant increases in urinary NGAL concentration have been demonstrated from normo‐ to micro‐to macroalbuminuric groups of patients with both T1DM and T2DM.37 Urinary NGAL correlates positively with glomerular hyperfiltration early in the clinical course of diabetes.