In high glucose‐stimulated podocytes, miRNA‐217 expression was elevated and inhibition of miRNA‐217 can protectively antagonize high glucose‐induced podocyte damage and insulin resistance by restoring the defective autophagy pathway via targeting PTEN.110 Several miRNAs have also been implicated in oxidative stress and ER stress in DKD pathogenesis. The gene discussed is PTEN; the disease is diabetic kidney disease.