Moreover, TGF‐β1 expression can be regulated by miRNAs.2 In diabetic mice (STZ and db/db), TGF‐β1 levels are found to be upregulated by miRNA‐192 and miRNA‐200b/c.72 In addition, recent studies also demonstrated miRNA‐22 inhibited bone morphogenetic protein‐6 (BMP‐6) and BMP‐7 and further increased TGF‐β1 signaling.77 miRNA‐433 increases TGF‐β1 signaling and fibrosis by targeting antizyme inhibitor 1, a regulator of polyamine synthesis.78 These miRNA‐regulated circuits may amplify TGF‐β1 signaling to contribute to the progression in DKD. This evidence concerns the gene TGFB1 and diabetic kidney disease.