In this study, we investigated the physiological impact of hepatic NPC1L1 on the risk of developing NAFLD using transgenic mice expressing human NPC1L1 in hepatocytes (L1‐Tg mice).6 Surprisingly, L1‐Tg mice fed a western diet exhibited steatosis within only a few weeks. Here, NPC1L1 is linked to metabolic dysfunction-associated steatotic liver disease.