Considering previous findings based on the studies using conventional or hepatic Tlr4 KO mice that suggest that TLR4 in hepatocytes plays a pivotal role during the early progression of HFD‐induced NAFLD,23, 24 the presence of hepatic NPC1L1 might accelerate the Tlr4‐related exacerbation of steatosis. Here, TLR4 is linked to metabolic dysfunction-associated steatotic liver disease.