HMGB1 and malignant colon neoplasm: In the meantime, other publications have demonstrated that epithelial cells might be capable of an active secretion of HMGB1 such as adipocytes, skin fibroblasts, or colon cancer cells49, 50, 51 implying that ethyl‐pyruvate may also prevent active secretion in these epithelial cells and would then not be specific of macrophages, undermining conclusions drawn from previous in vivo works using ethyl pyruvate.