In contrast, a recent study by Ge et  al, using macrophage‐specific genetic ablation (LysM‐CRE) or neutralization strategies demonstrates that macrophage and hepatocyte‐derived HMGB1 rather participates in liver fibrosis.41 Employing cell‐specific knockout of HMGB1 in macrophages in vivo, our report questions the contribution of a prototypical DAMP or pro‐inflammatory cytokine HMGB1 in the pathogenesis of fibrosis. The gene discussed is HMGB1; the disease is Hepatic fibrosis.