GSN and breast cancer: For example, hepatoma‐derived growth factor (HDGF), a heparin binding protein, identified only in CAB patients has previously been reported to have a putative role in carcinogenesis and metastatic invasiveness of breast cancer through epithelial‐mesenchymal transition (EMT).44 Similarly, gelsolin, a tumor suppressor protein, was upregulated in CAB patients, while it is downregulated in CAO subjects.