Other oncoproteins previously identified were known to be involved in progression and development of various cancerous tissues such as esophageal squamous cell carcinoma (ESCC), and breast and ovarian cancers.52, 53, 54 For example, suprabasin (SBSN), showed no change in abundance in CAB and CAO subjects but was upregulated in CAOAC patients, which may be in response to neoadjuvant paclitaxel and carboplatin drugs. This evidence concerns the gene SBSN and esophageal squamous cell carcinoma.