TP53 and cytomegalovirus infection: Nuclear proteins were selected for the cleavage assays because most p53 is located in the nuclei of HCMV‐infected cells.44 Furthermore, as HCMV infection progresses, a series of cellular physiologic responses occur.37, 38, 39 The availability of viral63, 64, 65, 66, 67, 68 and cellular molecules that can interact with p53 changes during the progression of HCMV infection, making it possible that p53 undergoes modifications that influence its susceptibility to calpain‐mediated cleavage.