VEGFA and neoplasm: It has been found that some tumors adapt, and become resistant to antiangiogenic therapy, and after anti‐VEGF therapy is terminated, the tumor vasculature can quickly reestablish, leading to the regrowth of the tumor.33, 34, 35 The development of PF144‐based cancer gene therapy system is still early in the development process, but even though the reduction in tumor growth was modest, the system should be further developed.