Although the CPP PepFect14 (PF14) is an efficient plasmid DNA delivery vector in vivo, it has shown high accumulation in the liver and lung.14 The nonspecificity of PF14 was tackled in a previous study, where PF14 was modified to create MMP‐2 activatable CPP PF144, which exhibited efficient tumor specificity by reporter gene delivery.14 Achieving a therapeutic effect by plasmid DNA delivery with CPPs would be a big step forward in nonviral systemic cancer gene therapy. The gene discussed is MMP2; the disease is cancer.