TGFB1 and Hyperglycemia: For example, using a standard low‐dose STZ model in mice, it was observed that triple knockout of the known diacylglycerol‐responsive TRPC channels (TRPC3, TRPC6, and TRPC7) reduced glomerular hypertrophy, albuminuria, and podocyte loss in diabetic animals, and also attenuated pro‐inflammatory TGF‐β signaling in glomeruli.29 Hyperglycemia was comparable in STZ‐treated triple knockout and wild‐type animals.