In fact, we have previously identified similar defects in Aldh3a2‐knockout mice using this test.19Aldh3a2‐knockout mice serve as a model for Sjögren‐Larsson syndrome,31 an autosomal recessive neurocutaneous disorder caused by mutations in the ALDH3A2 gene and characterized by spastic paraplegia and ichthyosis32—symptoms also observed in patients with the ELOVL1 mutation. This evidence concerns the gene ELOVL1 and neurocutaneous syndrome.