Another cardiac glycoside, bufalin, can inhibit tumor necrosis factor (TNF), IFN, and CXCL‐8.51 These novel anti‐inflammatory effects could be related to the modulation of autophagic flux and thus relevant to COPD that is associated with chronic inflammation and autoimmunity.12 The gene discussed is CXCL8; the disease is chronic obstructive pulmonary disease.