We did not specifically assess the role of p53 in sensitivity to AgNPs as almost all TNBC cell lines (including the 4 used in our study) are p53 mutants, and up to 80% of TNBC patients have mutant p53.70 However, a previous report has shown that AgNPs are able to induce p53‐independent cancer cell apoptosis in both p53 wild type and p53‐mutant osteosarcoma cells.71 This evidence concerns the gene TP53 and cancer.