First, in human adenocarcinoma HT29 cells, and then in immortalized murine microglial BV2 cells, where we co-incubated a mixture of human or murine TNF-α, Smac mimetic birinapant, pan-caspase inhibitor Z-VAD-FMK29 or Z-VAD-FMK alone30, and tested compounds at 10 μM for 24 h. This evidence concerns the gene TNF and adenocarcinoma.