The common signaling pathways from the brain in the three IBS models could be grouped into 13 principal pathways, namely, 14–3-3-mediated signaling, breast cancer regulation by stathmin 1, clathrin-mediated endocytosis signaling, aldosterone signaling in epithelial cells, epithelial adherens junction signaling, glycolysis I, integrin signaling, mitochondrial dysfunction, modeling of epithelial adherens junctions, protein ubiquitination pathway, Sertoli cell-Sertoli cell junction signaling, synaptic long-term potentiation and TCA cycle II. This evidence concerns the gene STMN1 and breast carcinoma.