PLA particles encapsulated with VEGF have been successfully used as nanosustained release microspheres, which induced proliferation and differentiation of adipose-derived stem cells (He et al., 2018). VEGF165 during encapsulation with PLA microparticles stimulated vasculogenesis and angiogenesis in an acute myocardial ischemia-reperfusion rat model (Formiga et al. 2010). Here, VEGFA is linked to myocardial ischemia.