Interphase FISH is routinely used for detection of t(14;18) translocation (i.e. IGH-BCL2) in FL (Vaandrager et al., 2000), t(11;14) translocation (i.e. IGH-CCND1) in MCL (Monteil et al., 1996), or t(8;14) translocation (i.e. IgH-MYC) in BL (Siebert et al., 1998) for diagnostic purposes. The gene discussed is BCL2; the disease is mantle cell lymphoma.