CEP290 and retinitis pigmentosa 1: Hematoxylin/eosin (H/E) staining revealed that subretinal delivery of AAV8-Nr2e3 at P0 rescued photoreceptor cells and helped maintain retinal integrity of RP retinas in all models tested at 1 month (rd1) post treatment, or 3–4 months (Rho−/−, RhoP23H, rd16, and rd7) post treatment (Fig. 4a).The attenuation of disease phenotype, as observed by ONL thickness, varied among each strain.