NTRK1 and spitz nevus: While Spitz nevi and atypical Spitz tumors with NTRK3 [14] and NTRK1 [15, 16] fusions, as well as pigmented spindle cell nevi of Reed with NTRK3 fusions [17], have shown distinctive clinical and histopathologic profiles, Spitz melanomas with these alterations generally do not show similarly distinguishing characteristics.