RAF1 and melanoma: Median TMB was 10.2 mut/Mb (range 0–57.4, 35% 10–20, 18% >20), similar to the primary skin and anus melanoma cohort without activating RAF1 fusions (median TMB = 13.8, 19% 10–20, 36% >20; p = 0.1, Mann–Whitney U test).