Given that polymorphisms in EV-A71 receptors, scavenger receptor class B member 2 (SCARB2) and P-selectin glycoprotein ligand-1 (PSGL-1), have been shown to affect EV-A71 susceptibility and infection respectively56, genomic variations within TREM-1 could also play a probable role in modulating EV-A71 infection and outcomes. This evidence concerns the gene SELPLG and infection.