For example, Zhang et al. showed that asparagine endopeptidase (AEP)-mediated tau cleavage at asparagines 255 and 368 is responsible for synaptic dysfunction and cognitive deficits of tau transgenic mice38 modeling frontotemporal dementia with parkinsonism39–41, and that the tau cleavage product ending C-terminally at asparagine 368 is present in AD brains42. This evidence concerns the gene MAPT and Alzheimer disease.