In accordance with this, a study from north-east suggests that IFN-γ expression appeared to be mediated by HLA-G in HNSCC tissues and through regulating HLA-G expression, HPV positive tumors could mediate immune suppression by manipulating SOCS, IFN-γ, IL-10 and cyclin D1 pathways29. This evidence concerns the gene CCND1 and head and neck squamous cell carcinoma.