HLA-G and neoplasm: Been highly aggressive in nature, HNSCC tumors have been involved in different mechanisms to evade immune recognition such as downregulation or loss of human leukocyte antigen (HLA) class I molecules, and/or disruption of the antigen-processing machinery (APM), expression of the non-classical human leukocyte antigen HLA-G, known to inhibit natural killer (NK) cells, T cells and antigen-presenting cells (APC), release of immunosuppressive factors into the tumour microenvironment e.g. IL-10, IL-6, transforming growth factor-β2,24–26.