INS and type 2 diabetes mellitus: In support of this, a study using a mouse model showed that subcutaneous flank fat transplantation into the abdominal cavity (visceral and subcutaneous depots) improved whole-body glucose homeostasis3, while increased insulin sensitivity in participants with type 2 diabetes treated with Pioglitazone administration increased the expression of genes related to mitochondrial biogenesis in aSAT21.