Moreover, the connection of sialylated IgG Fc-N-glycans and dendritic-cell-specific ICAM-3 grabbing non-integrin (DCSIGN in human/SIGN-R1 in mice) might use as stimulant factors for overcoming the inflammatory process and/or depression through identifying an endogenic factor to control the Th2 mechanical pathway to sustain the body homeostasis46. This evidence concerns the gene ICAM3 and depressive disorder.