NCAM1 and schizophrenia: Another glycan structure, core fucose, has also been reported to be reduced in schizophrenia.54 Core fucose is produced by the activity of α-1,6-fucosyltransferase 8 (FUT8), and FUT8 protein levels are reduced in schizophrenia.54 Interestingly, core fucosylation of N-glycans appears to be a prerequisite of PSA attachment.105 Thus, reduced FUT8 expression may also contribute to lower levels of PSA-NCAM in schizophrenia.