Interestingly, the level of octanoylated ghrelin in patient serum did not change over a 16-week course of olanzapine administration in the face of reduced total ghrelin at 8-, 12-, and 16-weeks of olanzapine treatment.157 This indicates that the relative amount of active versus inactive (non-octanoylated) ghrelin is increased with antipsychotic treatment, and suggests a potential mechanism contributing to antipsychotic-induced metabolic dysregulation in schizophrenia. Here, GHRL is linked to schizophrenia.