MAPT and Alzheimer disease: Using metabolomics data from 1517 participants of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohorts, we investigated how sex modifies the associations of representative A-T-N biomarkers54,55 (A: CSF Aβ1–42 pathology; T: CSF p-tau; N: region of interest (ROI)-based glucose uptake measured by [18F] fluorodeoxyglucose-positron emission tomography (FDG-PET)) with 139 blood metabolites using stratified analyses and systematic comparison of effects between men and women.