With the development of molecular biology theory and sequencing technology, a variety of genes related to hereditary dRTA and their mutations have been reported, including at least three different gene mutations: SLC4A1, ATP6V1B1, ATP6V0A4, encoding exchanger AE1 of Cl−/HCO3−, B1 subunit and a4 subunit of V-ATPase, respectively4,14,15. The gene discussed is ATP6V1B1; the disease is distal renal tubular acidosis.