PPP1R8 and hepatocellular carcinoma: For that reason, we compared the response of liver control mice (CTRs; Ppp1r8fl/+/Tg(Alfp-Cre)) and NIPP1 liver knockout mice (LKOs; Ppp1r8fl/−/Tg(Alfp-Cre)) to chemically induced hepatocellular carcinoma (HCC).