Although a previous study showed that microRNA 101 (miR101) inhibits POMP-mediated assembly of the 20S proteasome and suppresses tumor growth (27), the POMP-ARE mutation assay results in this study indicate that the upregulation of the NRF3-POMP axis enhances 20S proteasome assembly and promotes tumorigenesis in an miR101-independent manner. The gene discussed is POMP; the disease is neoplasm.