TFF2 and neoplasm: Considering that aberrant methylation of TFF2 were involved in the carcinogenesis of tumor, we carried out co-expression analysis between MUC1 and methylation of CpG loci located in TFF2. The results showed that the expression level of MUC1 was reversely related to the methylation status of TFF2. It has been established that epigenetic dysregulation in promoter of genes plays an important role in the development of GC [43, 44].