TP53 and pancreatic neoplasm: In pancreatic cancer cells, TP53 can increase glucose uptake by increasing paraoxonase 2 expression and impairing the expression of TP53-induced glycolysis and apoptosis regulator (TIGAR), which degrades fructose-2,6-bisphosphate, an effective enhancer of glycolysis, to fructose-6-phosphate [40, 57, 58].