HMGCR and pancreatic neoplasm: In pancreatic cancer, many enzymes participating in de novo fatty acids and cholesterol synthesis are obviously upregulated, including citrate synthase (CS), ATP citrate lyase (ACLY), fatty acid synthase (FASN), stearoyl-CoA desaturase (SCD1) and 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) [78, 79] (Fig. 1).