TP53 and pancreatic neoplasm: However, pancreatic cancer cells with normal TP53 status are resistant to LDHA inhibition due to decreased dependence on glycolysis [57].In addition to KRAS and TP53 signaling in pancreatic cancer cells, LDHA could also be comprehensively regulated by deacetylation modification and other oncogenic transcription factors, such as Forkhead box protein M1 (FOXM1) [60, 61].