TP53 and familial pancreatic carcinoma: Moreover, mutant TP53 in pancreatic cancer cells also maintains the cytoplasmic stabilization of glyceraldehyde-3-phosphate dehydrogenase, a key enzyme in glycolysis, to support the Warburg effect and confer sensitivity to glycolysis inhibitors (2-deoxyglucose, also known as 2-DG) [59].