For PTX resistance, multiple regulatory axes have been found, including the UCA1/miR-129/ABCB1 axis, the miR-874/serine/threonine-protein kinase 2 (SIK2) axis, the miR-383-5p/TRIM27 axis, and the miR-1246/ caveolin 1 (CAV1)/p-gp/M2-type macrophage axis [117–120], which provide some new mechanistically therapeutic approaches to overcome chemoresistance and tumor progression. The gene discussed is PGP; the disease is neoplasm.