NOTCH3 and CADASIL: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (OMIM: 125310) is an autosomal dominant small vessel disease predominantly caused by mutations in NOTCH3 gene (HGNC ID: 7883), which encodes internal, external and transmembrane domains of NOTCH3 protein.