Among the top three papers, the first paper, by Crowther et al., titled “Effect of treatment of gestational diabetes mellitus on pregnancy outcomes,” published in 2005 in the New England Journal of Medicine, had the highest number of citations and evaluated the efficacy of dietary advice, blood glucose monitoring, and insulin therapy (by comparing the intervention group to a control group receiving only routine care) in treating gestational diabetes in pregnant women to prevent perinatal complications [32]. The gene discussed is INS; the disease is gestational diabetes.