Although the epidermal expression density of c-kit was increased in the lesional skin of Riehl’s melanosis (H score, mean ± SD = 30.29 ± 7.97) compared to perilesional skin (H score, mean ± SD = 27.85 ± 2.64) and in healthy controls (H score, mean ± SD = 22.19 ± 2.38), the difference was not statistically significant (Figure 5). This evidence concerns the gene KIT and freckles.