Also, the number of CD68-positive cells was increased in the lesional skin of Riehl’s melanosis (mean ± SD = 16.66 ± 6.19) compared to perilesional normal-appearing skin (mean ± SD = 6.67 ± 4.21; p < 0.01) and healthy controls (mean ± SD = 2.25 ± 1.35; p < 0.001; Figure 3). Here, CD68 is linked to freckles.