In addition, some MCPH genes function in pathways known to be important for stem cell self-renewal, such as the Wnt (MCPH5 and MCPH18), Notch (MCPH12), Hippo (MCPH3, MCPH19, MCPH20 and MCPH24), and Shh (MCPH7 and MCPH12), all of which were previously identified as being relevant to cancer (Table 2). The gene discussed is COPB2; the disease is cancer.