For example, CerS1 generates C18-ceramide, mediating cell death and tumor suppression in acute myeloid leukemia (AML) and head and neck squamous cell carcinoma (HNSCC) [24,25], while CerS6 has an antiapoptotic role in ER stress responses and produces mainly C16-ceramide [26]. This evidence concerns the gene CERS1 and neoplasm.