CERS6 and acute myeloid leukemia: For example, CerS1 generates C18-ceramide, mediating cell death and tumor suppression in acute myeloid leukemia (AML) and head and neck squamous cell carcinoma (HNSCC) [24,25], while CerS6 has an antiapoptotic role in ER stress responses and produces mainly C16-ceramide [26].