SPARC and periodontitis: Although several studies [9,10,11] have investigated various biomarkers such as osteocalcin (OC), osteonectin (ON), and deoxypyridinoline-containing degradation fragment of the C-terminal telopeptide region of type I collagen (CTX), there are still no conclusive results regarding the most appropriate biomarker of bone turnover in adults with periodontitis.