Similarly, for migraine, a total of 17 genes (PLCE1, PLCE1-AS1, MRVI1, LRP1, STAT6, MEF2D, PRDM16, MROH2A, TRPM8, POC5, FHL5, KCNK5, PHACTR1, UFL1, TMEM91, MSL3P1, ANKDD1B) were genome-wide significant (Supplementary Table S6) in the gene-based analysis (at 2.92 × 10−6 threshold). This evidence concerns the gene IRAG1 and migraine disorder.