Supporting these results, other groups reported the pro-apoptotic activity of plants of the genus Maytenus. In this sense, total extracts of Maytenus royleanus showed potent antiproliferative and pro-apoptotic effects in human prostate cancer cells promoting the activation of Caspase-3 and PARP cleavage [38]. The gene discussed is CASP3; the disease is prostate carcinoma.