CD40LG and infection: A study with the anti-capsular IgM mAbs 12A1 and 13F1, which are protective and nonprotective, respectively, and are derived from the same B cell, showed that IgM efficacy against C. neoformans depends on the route of infection, inoculum, and Ab dose, in addition to their capacity to promote opsonization and agglutination in vivo [89].